obesity
- Flight activity and glycogen depletion on a low-carbohydrate diet
Summary: On a low-carbohydrate diet, flies experience a reduction in glycogen stores yet increase flight activity without changing rates of glycogen depletion.
- Thermo-TRPs and gut microbiota are involved in thermogenesis and energy metabolism during low temperature exposure of obese mice
Summary: Thermo-TRPs and gut microbiota are involved in attenuating diet-induced obesity during low temperature exposure in C57BL/6J mice.
- Parasitic gut infection in Libellula pulchella causes functional and molecular resemblance of dragonfly flight muscle to skeletal muscle of obese vertebrates
Summary: Similarity of effects of parasitic infections on muscle properties in flying insects to that of obesity in vertebrates enhances support for the concept that metabolic disease is not limited to vertebrates, and can be mediated by environmental factors.
- The evolution of body fatness: trading off disease and predation risk
Summary: Body fat is essential to survival – but having too much is detrimental. This paper develops an evolutionary model where disease risk pushes fat storage up while predation risk pushes it down. These patterns result in a system with dual intervention points at low and high levels of adiposity.
- The role of gp130 receptor cytokines in the regulation of metabolic homeostasis
Summary: Taken together, there is a great body of evidence suggesting that novel therapeutics to treat obesity and T2D can be developed by targeting gp130 ligands.