Table 2.

Pharmacological drugs used in this study

DrugsActionWorking dilution (mol l–1)Source
Extrinsic control
   AdrenalineNeurotransmitter10–3Sigma Chemical Co. (St Louis, MO, USA)
   NoradrenalineNeurotransmitter10–3Fluka (Buchs, Switzerland)
   CarbacholNeurotransmitter10–3Sigma
   5-HTNeurotransmitter10–3Sigma
   GABANeurotransmitter10–3Sigma
   PRLHormone10–5–10–8Sigma
   MTHormone10–4–10–7Acros Organics (Pittsburgh, PA, USA)
   α-MSHHormone10–6–10–7Sigma
   LuzindoleAntagonist MT1/MT210–4Sigma
   4P-PDOTAntagonist MT22×10–4–2×10–7Tocris Bioscience (Ellisville, MO, USA)
Intrinsic control
   dibutyryl-cAMPcAMP analogue (cAMP↓)10–4Sigma
   ForskolinAdenylyl cyclase activator (cAMP↓)10–4Sigma
   SQ22,536Adenylyl cyclase inhibitor (cAMP↑)10–5Sigma
   MDL-12,330AAdenylyl cyclase inhibitor (cAMP↑)10–5Sigma
   1,2,3,4,5,6-HexabromocyclohexaneJAK2 inhibitor (JAK2↓)10–4Calbiochem Merck (Darmstadt, Germany)
  • PRL, protein; MT, melatonin; a-MSH, a-melanocyte-stimulating hormone; 5-HT, serotonin