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Accepted Manuscript
Research Article
Nociceptive neurons respond to multimodal stimuli in Manduca sexta
Daniel P. Caron, Martha Rimniceanu, Anthony E. Scibelli, Barry A. Trimmer
Journal of Experimental Biology 2020 : jeb.218859 doi: 10.1242/jeb.218859 Published 13 January 2020
Daniel P. Caron
Tufts University, Department of Biology, 200 Boston Avenue, Suite 2600, MA 02155, USA
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Martha Rimniceanu
Tufts University, Department of Biology, 200 Boston Avenue, Suite 2600, MA 02155, USA
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Anthony E. Scibelli
Tufts University, Department of Biology, 200 Boston Avenue, Suite 2600, MA 02155, USA
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Barry A. Trimmer
Tufts University, Department of Biology, 200 Boston Avenue, Suite 2600, MA 02155, USA
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  • For correspondence: barry.trimmer@tufts.edu
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Abstract

The caterpillar Manduca sexta produces a highly stereotyped strike behavior in response to noxious thermal or mechanical stimuli to the abdomen. This rapid movement is targeted to the site of the stimulus, but the identities of the nociceptive sensory neurons are currently unknown. It is also not known if both mechanical and thermal stimuli are detected by the same neurons. Here we show that the likelihood of a strike increases with the strength of the stimulus and that activity in nerves innervating the body wall increases rapidly in response to noxious stimuli. Both mechanical and thermal stimuli to the dorsal body wall activate the same sensory unit suggesting it represents a multimodal neuron. This is further supported by the effects of rapidly repeated thermal or mechanical stimuli which cause a depression of neuronal responsiveness that is generalized across modalities. Mapping the receptive fields of neurons responding to strong thermal stimuli indicate that these multimodal, nociceptive units are produced by class γ multi-dendritic neurons in the body wall.

  • Received November 19, 2019.
  • Accepted January 6, 2020.
  • © 2020. Published by The Company of Biologists Ltd
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Keywords

  • Nociception
  • Caterpillar
  • Manduca sexta
  • Strike
  • Multimodal
  • Multi-dendritic

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Accepted Manuscript
Research Article
Nociceptive neurons respond to multimodal stimuli in Manduca sexta
Daniel P. Caron, Martha Rimniceanu, Anthony E. Scibelli, Barry A. Trimmer
Journal of Experimental Biology 2020 : jeb.218859 doi: 10.1242/jeb.218859 Published 13 January 2020
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Accepted Manuscript
Research Article
Nociceptive neurons respond to multimodal stimuli in Manduca sexta
Daniel P. Caron, Martha Rimniceanu, Anthony E. Scibelli, Barry A. Trimmer
Journal of Experimental Biology 2020 : jeb.218859 doi: 10.1242/jeb.218859 Published 13 January 2020

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