Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About JEB
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contact JEB
    • Subscriptions
    • Advertising
    • Feedback
    • Institutional usage stats (logged-in users only)
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Journal of Experimental Biology
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Journal of Experimental Biology

  • Log in
Advanced search

RSS  Twitter  Facebook  YouTube  

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About JEB
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contact JEB
    • Subscriptions
    • Advertising
    • Feedback
    • Institutional usage stats (logged-in users only)
Research Article
Different fuel regulation in two types of myofiber results in different antioxidant strategies in Daurian ground squirrels (Spermophilus dauricus) during hibernation
Shen-Hui Xu, Wei-Wei Fu, Jie Zhang, Hui-Ping Wang, Kai Dang, Hui Chang, Yun-Fang Gao
Journal of Experimental Biology 2021 224: jeb231639 doi: 10.1242/jeb.231639 Published 18 January 2021
Shen-Hui Xu
1Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an Shaanxi 710069, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shen-Hui Xu
Wei-Wei Fu
2Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an Shaanxi 710032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Wei-Wei Fu
Jie Zhang
1Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an Shaanxi 710069, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hui-Ping Wang
1Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an Shaanxi 710069, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kai Dang
3Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an Shaanxi 710072, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hui Chang
1Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an Shaanxi 710069, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yun-Fang Gao
1Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an Shaanxi 710069, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yun-Fang Gao
  • For correspondence: gaoyunf@nwu.edu.cn
  • Article
  • Figures & tables
  • Info & metrics
  • PDF
Loading

ABSTRACT

We previously showed that different skeletal muscles in Daurian ground squirrels (Spermophilus dauricus) possess different antioxidant strategies during hibernation; however, the reason for these varied strategies remains unclear. To clarify this issue, we studied REDD1, FOXO4, PGC-1α, FOXO1 and atrogin-1 proteins to determine the potential cause of the different antioxidant strategies in Daurian ground squirrels during hibernation, and to clarify whether different strategies affect atrophy-related signals. Results showed that the soleus (SOL) muscle experienced intracellular hypoxia during interbout arousal, but no oxidative stress. This may be due to increased PGC-1α expression enhancing antioxidant capacity in the SOL under hypoxic conditions. Extensor digitorum longus (EDL) muscle showed no change in oxidative stress, hypoxia or antioxidant capacity during hibernation. The FOXO1 and PGC-1α results strongly suggested differentially regulated fuel metabolism in the SOL and EDL muscles during hibernation, i.e. enhanced lipid oxidation and maintained anaerobic glycolysis, respectively. Atrogin-1 expression did not increase during hibernation in either the SOL or EDL, indicating that protein synthesis was not inhibited by atrogin-1. Thus, our results suggest that different fuel regulation may be one mechanism related to antioxidant defense strategy formation in different kinds of skeletal muscle fibers of Daurian ground squirrels during hibernation.

Footnotes

  • Competing interests

    The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

  • Author contributions

    Conceptualization: S.X., W.F., H.W., Y.G.; Methodology: S.X.; Software: S.X.; Validation: S.X., W.F.; Formal analysis: S.X.; Investigation: S.X., W.F.; Resources: S.X., W.F.; Data curation: S.X., J.Z.; Writing - original draft: S.X.; Writing - review & editing: W.F., J.Z., H.W., K.D., H.C., Y.G.; Visualization: H.C.; Supervision: J.Z., H.W., K.D., Y.G.; Project administration: Y.G.; Funding acquisition: H.W., K.D., H.C., Y.G.

  • Funding

    This work was supported by funds from the National Natural Science Foundation of China (no. 31772459), Opening Foundation of Shaanxi Key Laboratory for Animal Conservation (Northwest University) (AC2019001) and Natural Science Foundation of Shaanxi Province (grant no. 2020JM-100).

  • Received June 20, 2020.
  • Accepted December 8, 2020.
  • © 2021. Published by The Company of Biologists Ltd
http://www.biologists.com/user-licence-1-1/
View Full Text

Log in using your username and password

Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$30.00 .

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

Keywords

  • Hibernation
  • Skeletal muscle
  • Fuel regulation
  • Antioxidant defense strategy
  • Ground squirrels

 Download PDF

Email

Thank you for your interest in spreading the word on Journal of Experimental Biology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Different fuel regulation in two types of myofiber results in different antioxidant strategies in Daurian ground squirrels (Spermophilus dauricus) during hibernation
(Your Name) has sent you a message from Journal of Experimental Biology
(Your Name) thought you would like to see the Journal of Experimental Biology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Research Article
Different fuel regulation in two types of myofiber results in different antioxidant strategies in Daurian ground squirrels (Spermophilus dauricus) during hibernation
Shen-Hui Xu, Wei-Wei Fu, Jie Zhang, Hui-Ping Wang, Kai Dang, Hui Chang, Yun-Fang Gao
Journal of Experimental Biology 2021 224: jeb231639 doi: 10.1242/jeb.231639 Published 18 January 2021
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Research Article
Different fuel regulation in two types of myofiber results in different antioxidant strategies in Daurian ground squirrels (Spermophilus dauricus) during hibernation
Shen-Hui Xu, Wei-Wei Fu, Jie Zhang, Hui-Ping Wang, Kai Dang, Hui Chang, Yun-Fang Gao
Journal of Experimental Biology 2021 224: jeb231639 doi: 10.1242/jeb.231639 Published 18 January 2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • References
  • Figures & tables
  • Info & metrics
  • PDF

Related articles

Cited by...

More in this TOC section

  • Angling gear avoidance learning in juvenile red sea bream: evidence from individual-based experiments
  • Tactile active sensing in an insect plant pollinator
  • Omega-3 fatty acids accelerate fledging in an avian marine predator: a potential role of cognition
Show more RESEARCH ARTICLE

Similar articles

Other journals from The Company of Biologists

Development

Journal of Cell Science

Disease Models & Mechanisms

Biology Open

Advertisement

Welcome to JEB’s new Editor Monica Daley

We are pleased to welcome Monica Daley to JEB’s Editorial team. Monica has had a long association with JEB before taking up her new role, overseeing peer review of neuromuscular physiology, terrestrial biomechanics and integrative physiology of locomotion.


In the field with Robyn Hetem

Continuing our fieldwork series, Robyn Hetem reflects on working with species ranging from aardvark to zebra, and the impact COVID-19 has had on fieldwork.


Read & Publish participation continues to grow

“It is particularly encouraging for early career researchers, as it allows them to display their research globally without the need to find costs to cover the open access option.”

Professor Fernando Montealegre-Z (University of Lincoln) shares his experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 150 institutions in 15 countries and four library consortia taking part – find out more and view our full list of participating institutions.


Nocturnal reef residents have deep-sea-like eyes

Fanny de Busserolles and colleagues from The University of Queensland have discovered that the eyes of nocturnal reef fish have multibank retinas, layers of photoreceptors, similar to the eyes of deep-sea fish that live in dim light conditions.


Mechanisms underlying gut microbiota–host interactions in insects

In their Review, Konstantin Schmidt and Philipp Engel summarise recent findings about the mechanisms involved in gut colonisation and the provisioning of beneficial effects in gut microbiota–insect symbiosis.

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About JEB
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists
  • Journal news

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Outstanding paper prize
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact JEB
  • Subscriptions
  • Advertising
  • Feedback

 Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992