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December, 2020; 223 (24)

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Cover: From flatworms and insects to frogs and turtles, embryos use disturbance cues and signals to inform hatching timing, yet mechanisms mediating mechanosensing in ovo are largely unknown. The arboreal embryos of red-eyed treefrogs, Agalychnis callidryas, hatch prematurely to escape predation, cued by physical disturbance in snake attacks. Jung et al. (jeb236141) provide evidence that the development of lateral line neuromasts mediates the earliest onset of mechanosensory-cued hatching. Functional neuromasts were treated to fluoresce using 4-di-2-ASP (pictured) and temporarily ablated to examine their role in vibration sensation in ovo. Photo credit: Julie Jung.

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