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Review
Evolution of neuropeptide signalling systems
Maurice R. Elphick, Olivier Mirabeau, Dan Larhammar
Journal of Experimental Biology 2018 221: jeb151092 doi: 10.1242/jeb.151092 Published 9 February 2018
Maurice R. Elphick
1School of Biological & Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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  • For correspondence: m.r.elphick@qmul.ac.uk
Olivier Mirabeau
2Genetics and Biology of Cancers Unit, Institut Curie, INSERM U830, Paris Sciences et Lettres Research University, Paris 75005, France
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Dan Larhammar
3Department of Neuroscience, Science for Life Laboratory, Uppsala University, Box 593, 75124 Uppsala, Sweden
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This article has a correction. Please see:

  • Correction: Evolution of neuropeptide signalling systems (doi:10.1242/jeb.151092) - October 01, 2018

ABSTRACT

Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological processes and behaviour in animals. However, determining the relationships and evolutionary origins of the heterogeneous assemblage of neuropeptides identified in a range of phyla has presented a huge challenge for comparative physiologists. Here, we review revolutionary insights into the evolution of neuropeptide signalling that have been obtained recently through comparative analysis of genome/transcriptome sequence data and by ‘deorphanisation’ of neuropeptide receptors. The evolutionary origins of at least 30 neuropeptide signalling systems have been traced to the common ancestor of protostomes and deuterostomes. Furthermore, two rounds of genome duplication gave rise to an expanded repertoire of neuropeptide signalling systems in the vertebrate lineage, enabling neofunctionalisation and/or subfunctionalisation, but with lineage-specific gene loss and/or additional gene or genome duplications generating complex patterns in the phylogenetic distribution of paralogous neuropeptide signalling systems. We are entering a new era in neuropeptide research where it has become feasible to compare the physiological roles of orthologous and paralogous neuropeptides in a wide range of phyla. Moreover, the ambitious mission to reconstruct the evolution of neuropeptide function in the animal kingdom now represents a tangible challenge for the future.

FOOTNOTES

  • Competing interests

    The authors declare no competing or financial interests.

  • Funding

    M.R.E. was supported by grants from the Biotechnology and Biological Sciences Research Council (BB/M001644/1) and the Leverhulme Trust (RGP-2013-351, RPG-2016-353). O.M. was supported by the Fondation pour la Recherche Médicale and the Association France Parkinson, and by grants awarded to Jean-Stephane Joly (Institut des Neurosciences Paris-Saclay, France) from the Agence Nationale de la Recherche. D.L. was supported by grants from Vetenskapsrådet (Swedish Research Council) and the Carl Tryggers Stiftelse för Vetenskaplig Forskning. Deposited in PMC for immediate release.

  • Supplementary information

    Supplementary information available online at http://jeb.biologists.org/lookup/doi/10.1242/jeb.151092.supplemental

  • © 2018. Published by The Company of Biologists Ltd
http://creativecommons.org/licenses/by/3.0

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Keywords

  • Evolution
  • Invertebrate
  • Neuropeptide
  • Phylogeny
  • Receptor
  • Vertebrate

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Review
Evolution of neuropeptide signalling systems
Maurice R. Elphick, Olivier Mirabeau, Dan Larhammar
Journal of Experimental Biology 2018 221: jeb151092 doi: 10.1242/jeb.151092 Published 9 February 2018
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Review
Evolution of neuropeptide signalling systems
Maurice R. Elphick, Olivier Mirabeau, Dan Larhammar
Journal of Experimental Biology 2018 221: jeb151092 doi: 10.1242/jeb.151092 Published 9 February 2018

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    • ABSTRACT
    • Introduction
    • Neuropeptide-type signalling systems in non-bilaterian metazoans
    • The evolution and diversity of neuropeptide signalling systems in the Bilateria
    • Neuropeptides and their receptors in vertebrates – the impact of genome doublings
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