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Energy demand
The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives
Theodore Garland, Jr, Heidi Schutz, Mark A. Chappell, Brooke K. Keeney, Thomas H. Meek, Lynn E. Copes, Wendy Acosta, Clemens Drenowatz, Robert C. Maciel, Gertjan van Dijk, Catherine M. Kotz, Joey C. Eisenmann
Journal of Experimental Biology 2011 214: 206-229; doi: 10.1242/jeb.048397
Theodore Garland Jr
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  • For correspondence: tgarland@ucr.edu
Heidi Schutz
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Mark A. Chappell
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Brooke K. Keeney
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Thomas H. Meek
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Lynn E. Copes
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Wendy Acosta
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Clemens Drenowatz
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Robert C. Maciel
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Gertjan van Dijk
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Catherine M. Kotz
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Joey C. Eisenmann
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Summary

Mammals expend energy in many ways, including basic cellular maintenance and repair, digestion, thermoregulation, locomotion, growth and reproduction. These processes can vary tremendously among species and individuals, potentially leading to large variation in daily energy expenditure (DEE). Locomotor energy costs can be substantial for large-bodied species and those with high-activity lifestyles. For humans in industrialized societies, locomotion necessary for daily activities is often relatively low, so it has been presumed that activity energy expenditure and DEE are lower than in our ancestors. Whether this is true and has contributed to a rise in obesity is controversial. In humans, much attention has centered on spontaneous physical activity (SPA) or non-exercise activity thermogenesis (NEAT), the latter sometimes defined so broadly as to include all energy expended due to activity, exclusive of volitional exercise. Given that most people in Western societies engage in little voluntary exercise, increasing NEAT may be an effective way to maintain DEE and combat overweight and obesity. One way to promote NEAT is to decrease the amount of time spent on sedentary behaviours (e.g. watching television). The effects of voluntary exercise on other components of physical activity are highly variable in humans, partly as a function of age, and have rarely been studied in rodents. However, most rodent studies indicate that food consumption increases in the presence of wheels; therefore, other aspects of physical activity are not reduced enough to compensate for the energetic cost of wheel running. Most rodent studies also show negative effects of wheel access on body fat, especially in males. Sedentary behaviours per se have not been studied in rodents in relation to obesity. Several lines of evidence demonstrate the important role of dopamine, in addition to other neural signaling networks (e.g. the endocannabinoid system), in the control of voluntary exercise. A largely separate literature points to a key role for orexins in SPA and NEAT. Brain reward centers are involved in both types of physical activities and eating behaviours, likely leading to complex interactions. Moreover, voluntary exercise and, possibly, eating can be addictive. A growing body of research considers the relationships between personality traits and physical activity, appetite, obesity and other aspects of physical and mental health. Future studies should explore the neurobiology, endocrinology and genetics of physical activity and sedentary behaviour by examining key brain areas, neurotransmitters and hormones involved in motivation, reward and/or the regulation of energy balance.

FOOTNOTES

  • Preparation of this manuscript was supported by US NSF grants IOB-0543429 (to T.G.) and BCS-0925793 (to L.E.C.) and by NIH/NIDDK R01 DK078985 (to C.M.K.). Deposited in PMC for release after 12 months.

  • List of abbreviations

    ADHD
    attention deficit hyperactivity disorder
    AEE
    activity energy expenditure
    BMR
    basal metabolic rate
    DEE
    daily energy expenditure
    DLW
    doubly labeled water
    ECS
    endocannabinoid system; a complex endogenous signaling system made up of transmembrane cannabinoid receptors, their ligands (endocannabinoids) and proteins involved in synthesis and modification of endocannabinoids
    FMR
    field metabolic rate
    GWAS
    genome wide-association study
    HR
    High Runner; four replicate lines of mice that have been bred for high voluntary wheel running on days 5 and 6 of a 6-day period of wheel access while they are young adults (Swallow et al., 1998)
    MVPA
    moderate-to-vigorous physical activity, as used in studies of humans
    NEAT
    non-exercise activity thermogenesis
    QTL
    quantitative trait locus
    SNP
    single nucleotide polymorphism
    SPA
    spontaneous physical activity
    TEF
    thermic effect of food
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    Energy demand
    The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives
    Theodore Garland, Jr, Heidi Schutz, Mark A. Chappell, Brooke K. Keeney, Thomas H. Meek, Lynn E. Copes, Wendy Acosta, Clemens Drenowatz, Robert C. Maciel, Gertjan van Dijk, Catherine M. Kotz, Joey C. Eisenmann
    Journal of Experimental Biology 2011 214: 206-229; doi: 10.1242/jeb.048397
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    Energy demand
    The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives
    Theodore Garland, Jr, Heidi Schutz, Mark A. Chappell, Brooke K. Keeney, Thomas H. Meek, Lynn E. Copes, Wendy Acosta, Clemens Drenowatz, Robert C. Maciel, Gertjan van Dijk, Catherine M. Kotz, Joey C. Eisenmann
    Journal of Experimental Biology 2011 214: 206-229; doi: 10.1242/jeb.048397

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    Article navigation

    • Top
    • Article
      • Summary
      • Introduction
      • Defining voluntary exercise and SPA
      • DEE and its components
      • Voluntary exercise, SPA and energy expenditure in human beings
      • Summary of experimental studies with humans
      • Studies of free-living humans
      • Voluntary exercise, SPA and food consumption in laboratory rodents
      • Energy intake, physical activity and obesity
      • Neurobiology of voluntary exercise and SPA
      • Neurobiology of voluntary exercise
      • Neurobiology of SPA and NEAT
      • Personality correlates of physical activity
      • Synthesis; physical activity, neurobiology and personality
      • Genetic basis of variation in physical activity and related phenotypes
      • Conclusions and future directions
      • Acknowledgements
      • FOOTNOTES
      • List of abbreviations
      • References
    • Figures & tables
    • Info & metrics
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