- A radical shift in perspective: mitochondria as regulators of reactive oxygen species
Summary: Mitochondria are often considered to be a source of harmful reactive oxygen species. Here, we explain how they may behave as regulators of hydrogen peroxide, an important ROS in cellular function.
- Development of endothermy and concomitant increases in cardiac and skeletal muscle mitochondrial respiration in the precocial Pekin duck (Anas platyrhynchos domestica)
Summary: Noteworthy increases in cardiac ventricle mass and in skeletal and cardiac muscle oxidative phosphorylation capacity arise when Pekin ducks hatch and attain an endothermic metabolic phenotype.
- Muscle memory and a new cellular model for muscle atrophy and hypertrophy
Summary: New evidence indicates that during hypertrophy, pre-existing muscle fibres recruit nuclei from satellite cells, which are not lost during atrophy. The new permanent myonuclei represent cellular memory facilitating subsequent growth.
- Skeletal muscle mass and composition during mammalian hibernation
Summary: Despite massive reductions in activity and nutrient intake during winter, hibernators largely preserve skeletal muscle. My review summarizes these data and explores potential mechanisms explaining this remarkable outcome.
- Molecular networks in skeletal muscle plasticity
Summary: A comprehensive review of the current state of research on the molecular networks that regulate skeletal muscle phenotypic plasticity with different types of exercise, disuse, ageing and disease.
- The role of gp130 receptor cytokines in the regulation of metabolic homeostasis
Summary: Taken together, there is a great body of evidence suggesting that novel therapeutics to treat obesity and T2D can be developed by targeting gp130 ligands.
- Muscle structural assembly and functional consequences
Summary: This review explains the contribution of early renaissance studies on human anatomy and physiology to our current understanding of the contractile behaviour and adaptations of skeletal muscle to overloading, unloading and ageing.
- Nebulin, a multi-functional giant
Summary: The giant protein nebulin is a multifunctional protein that impacts skeletal muscle function in diverse ways.
- Bridging the myoplasmic gap II: more recent advances in skeletal muscle excitation–contraction coupling
Summary: This article reviews recent work regarding the communication between the L-type Ca2+ channel (CaV1.1) and the type 1 ryanodine receptor (RyR1) that supports excitation–contraction coupling in skeletal muscle.