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About the Cover
Cover: An endocrine Inka cell (green) situated on the respiratory trachea (purple) in a larval fruit fly, Drosophila melanogaster. The Inka cells release ecdysis triggering hormone (ETH) to trigger ecdysis, a stereotyped sequence of behaviours that insects use to shed the old cuticle at the culmination of each moult. Gauthier and Hewes (pp. 1803−1815) show that ETH synthesis is regulated by two evolutionarily conserved transcription factors, DIMM and CRC, the latter of which acts through conserved sequences contained within the ETH gene promoter (inset).
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