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Berridge, M. J (1993). Inositol trisphosphate and calcium signalling. Nature_Fb_361 , 315\320325. M. H. NATHANSON, A. F. O'NEILLANDA. D. BURGSTAHLERFig.5. Subcellular distribution of InsP3 receptors in skate hepatocytes, as determined by confocal immunofluorescence microscopy. (A) Rhodamine\320phalloidin labeling of an isolated cluster of skate hepatocytes identifies the plasma membranes of the cells. Labeling is most intense along the apical membranes. (B) Distribution of the type I InsP3R, labeled with antibody T210. No labeling was seen in hepatocytes stained with primary antibody directed against the type II or type III InsP3R, or in cells stained with secondary antibody alone. (C) Superimposed images A and B, demonstrating the nonpolarized distribution of the type I InsP3R in skate hepatocytes. Receptor labeling is diffusely distributed, rather than being concentrated in an apical trigger zone. Scale bar, 50m. 3055 Ca2+waves in skate hepatocytes_Fb_Bezprozvanny, I., Watras, J. and Ehrlich, B. E. (1991). Bell-shaped calcium-response curves of Ins(1,4,5)P3-and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 351, 751-.

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