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ACKERMAN, S. H. AND TZAGOLOFF, A.(1990a). ATP10, a

yeast nuclear gene required for the assembly of the mitochondrial F1ÐFo complex. J. biol. Chem. 265, 9952Ð9959. ACKERMAN, S. H. AND TZAGOLOFF, A. (1990b). Identification of two nuclear genes (ATP11, ATP12) required for assembly of the yeast F1-ATPase. Proc. natn. Acad. Sci. U.S.A. 87, 4986Ð4990. ADACHI, I., PUOPOLO, K., MARQUEZ-STERLING, N., ARAI, H. AND FORGAC, M.(1990). Dissociation, crosslinking and glycosylation of the coated-vesicle proton pump. J. biol. Chem. 265, 967Ð973. ANRAKU, Y., H IRATA, R., U MEMOTO, N. AND OHYA, Y. (1991). Molecular aspect of the yeast vacuolar membrane proton ATPase. In New Era of Bioenergetics (ed Y. Mukohata), pp. 133Ð168. New York: Academic Press. ANRAKU, Y., HIRATA, R., WADA, Y. AND OHYA, Y.(1992). Molecular genetics of the yeast vacuolar H +ATPase. J. exp. Biol. 172, ARIS, J. P., KLIONSKY, D. J. AND SIMONI, R. D.(1985). The Fo subunits of the Escherichia coli F1Fo-ATP synthase are sufficient to form a functional proton pore. J. biol. Chem. 260, 11207Ð11215. 102 P. M. KANE BELTRAN, C., KOPECKY, J., PAN, Y.-C. E., NELSON, H. AND NELSON, N. (1992). Cloning and mutational analysis of the gene encoding subunit C of yeast vacuolar H+-ATPase. J. biol. Chem. 267, 774Ð779. BOWMAN, B. J., DSCHIDA, W. J., HARRIS, T. AND BOWMAN, E. J. (1989). The vacuolar ATPase of Neurospora crassa contains an F1-like structure. J. biol. Chem. 264, 15606Ð15612. BURNS, D. J. AND LEWIN, A. S. (1986). The rate of import and assembly of F1-ATPases in Saccharomyces cerevisiae. J. biol. Chem. 261, 12066Ð12073. CRIVELLONE, M. D., WU, M. AND TZAGOLOFF, A. (1988). Assembly of the mitochondrial membrane system. Analysis of structural mutants of the yeast coenzyme QH2Ðcytochrome c reductase complex. J. biol. Chem. 263, 14323Ð14333. ELLIS, R. J. AND VANDER VIES, S. M.(1991). Molecular chaperones. A. Rev. Biochem. 60, 321Ð347. FOURY, F. (1990). The '31 kD' polypeptide is an essential subunit of the vacuolar ATPase in Saccharomyces cerevisiae. J. biol. Chem. 265, 18554Ð18560. FUCHS, R., MALE, P. AND MELLMAN, I. (1989). Acidification and ion permeabilities of highly purified rat liver endosomes. J. biol. Chem. 264, 2212Ð2220. GETHING, M. J. AND SAMBROOK, J. (1992). Protein folding in the cell. Nature 355, 33Ð45. HIRATA, R., OHSUMI, Y., NAKANO, A., KAWASAKI, H., SUZUKI, K. AND ANRAKU, Y. (1990). Molecular structure of a gene, VMA1, encoding the catalytic subunit of H+-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. J. biol. Chem. 265, 6726Ð6733. HURTLEY, S. M. AND HELENIUS, A.(1989). Protein oligomerization in the endoplasmic reticulum. A. Rev. Cell Biol. 5, 277Ð307. KANE, P. M., KUEHN, M. C., HOWALD-STEVENSON, I. AND STEVENS, T. H.(1992). Assembly and targeting of peripheral and integral membrane subunits of the yeast vacuolar H+-ATPase. J. biol. Chem. 267, 447Ð454. KANE, P. M. AND STEVENS, T. H. (1992). Subunit composition, biosynthesis and assembly of the yeast vacuolar proton-translocating ATPase. J. Bioenerg. Biomembr. 24, 383Ð393. KANE, P. M., YAMASHIRO, C. T., ROTHMAN, J. H. AND STEVENS, T. H. (1989a). Protein sorting in yeast: The role of the vacuolar proton-translocating ATPase. J. Cell Sci. (Suppl.) 11, 161Ð178. KANE, P. M., YAMASHIRO, C. T. AND STEVENS, T. H. (1989b). Biochemical characterization of the yeast vacuolar H+-ATPase. J. biol. Chem. 264, 19236Ð19244. KANE, P. M., YAMASHIRO, C. T., WOLCZYK, D. R., NEFF, N., GOEBL, M. AND STEVENS, T. H. (1990). Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H+adenosine triphosphatase. Science 250, 651Ð657. KLIONSKY, D. J. AND EMR, S. D. (1989). Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase. EMBO J. 8, 2241Ð2250. KLIONSKY, D. J. AND SIMONI, R. D. (1985). Assembly of a functional F1 of the proton-translocating ATPase of Escherichia coli. J. biol. Chem. 260, 11200Ð11206. MANOLIOS, N., LETOURNEUR, F., BONIFICANO, J. S. AND KLAUSNER, R. D. (1991). Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor. EMBO J. 10, 1643Ð1651. MANOLSON, M. F., PROTEAU, D., PRESTON, R. A., STENBIT, A., ROBERTS, B. T., HOYT, M. A., PREUSS, D., MULHOLLAND, J., BOTSTEIN, D. AND JONES, E. W. (1992). The VPH1 gene encodes a 95 kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H+-ATPase. J. biol. Chem. (in press).

MELLMAN, I., FUCHS, R. AND HELENIUS, A.(1986). Acidification of the endocytic and exocytic pathways. A. Rev. Biochem. 55, 663Ð700. MORIYAMA, Y. AND NELSON, N. (1989). Cold inactivation of vacuolar proton-ATPases. J. biol. Chem. 264, 3577Ð3582. NELSON, H., MANDIYAN, S. AND NELSON, N.(1989). A conserved gene encoding the 57-kD subunit of the yeast vacuolar H+-ATPase. J. biol. Chem. 264, 1775Ð1778. (Corrigendum, 264, 5313). NELSON, H. AND NELSON, N. (1989). The progenitor of ATP synthases was closely related to the current vacuolar H+-ATPase. FEBS Lett. 247, 147Ð153. NELSON, H. AND NELSON, N. (1990). Disruption of genes encoding subunits of yeast vacuolar H+ATPase causes conditional lethality. Proc. natn. Acad. Sci. U.S.A. 87, 3503Ð3507. NELSON, N. AND TAIZ, L.(1989). The evolution of H +-ATPases. Trends biochem. Sci. 14, 113Ð116. NISHIKAWA, S., UMEMOTO, N., OHSUMI, Y., NAKANO, A. AND ANRAKU, Y.(1990). Biogenesis of vacuolar membrane glycoproteins of yeast Saccharomyces cerevisiae. J. biol. Chem. 265, 7440Ð7448. Yeast vacuolar ATPase assembly NOUMI, T., BELTRAN, C., NELSON, H. AND NELSON, N. (1991). Mutational analysis of yeast vacuolar H+ATPase. Proc. natn. Acad. Sci. U.S.A. 88, 1938Ð1942. OHYA, Y., UMEMOTO, N., TANIDA, I., OHTA, A., IIDA, H. AND ANRAKU, Y. (1991). Calcium-sensitive cls mutants of Saccharomyces cerevisiae showing a pet-phenotype are ascribable to defects of vacuolar membrane H+-ATPase activity. J. biol. Chem. 266, 13971Ð13977. PRESTON, R. A., MURPHY, R. F. AND JONES, E. W.(1989). Assay of vacuolar pH in yeast and identificaton of acidification-defective mutants. Proc. natn. Acad. Sci. U.S.A. 86, 7027Ð7031. PUOPOLO, K. AND FORGAC, K. (1990). Functional reassembly of the coated vesicle proton pump. J. biol. Chem. 265, 14836Ð14841. RAYMOND, C. K., O'HARA, P. J., EICHINGER, G., ROTHMAN, J. H. AND STEVENS, T. H. (1990). Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle. J. Cell Biol. 111, 877Ð892. ROBERTS, C. J., POHLIG, G., ROTHMAN, J. H. AND STEVENS, T. H. (1989). Structure, biosynthesis and localization of dipeptidyl aminopeptidase B, an integral membrane glycoprotein of the yeast vacuole. J. Cell Biol. 108, 1363Ð1373. ROTHMAN, J. H., HOWALD, I. AND STEVENS, T. H.(1989a). Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cervisiae. EMBO J. 8, 2057Ð2065. ROTHMAN, J. H. AND STEVENS, T. H. (1986). Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell 47, 1041Ð1051. ROTHMAN, J. H., YAMASHIRO, C. T., RAYMOND, C. K., KANE, P. M. AND STEVENS, T. H. (1989b). Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins. J. Cell Biol. 109, 93Ð100. ROTHSTEIN, R. (1991). Targeting, disruption, replacement and allele rescue: Integrative DNA transformation in yeast. Meth. Enzymol. 194, 281Ð301. SCHATZ, G. (1968). Impaired binding of mitochondrial adenosine triphosphatase in the cytoplasmic 'petite' mutant of Saccharomyces cerevisiae. J. biol. Chem. 243, 2192Ð2199. SHIH, C.-K., WAGNER, R., FEINSTEIN, S., KANIK-ENNULAT, C. AND NEFF, N. (1988). A dominant trifluoperazine resistance gene for Saccharomyces cerevisiae has homology with FoF1 ATP-synthase and confers calcium-sensitive growth. Molec. cell. Biol. 8, 3094Ð3103. UCHIDA, E., OHSUMI, Y. AND ANRAKU, Y.(1985). Purification and properties of H+-translocating, Mg2+adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. J. biol. Chem. 260, 1090Ð1095. UCHIDA, E., OHSUMI, Y. AND ANRAKU, Y. (1988). Characterization and function of catalytic subunit a of proton-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. J. biol. Chem. 263, 45Ð51. UMEMOTO, N., OHYA, Y. AND ANRAKU, Y. (1991). VMA11, a

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C. Landolt-Marticorena, W. H. Kahr, P. Zawarinski, J. Correa, and M. F. Manolson
Substrate- and Inhibitor-induced Conformational Changes in the Yeast V-ATPase Provide Evidence for Communication between the Catalytic and Proton-translocating Sectors
J. Biol. Chem., September 10, 1999; 274(37): 26057 - 26064.
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