ANDERSON, E. AND HARVEY, W. R.(1966). Active transport by the Cecropia midgut. II. Fine structure of
the midgut epithelium. J. Cell Biol. 31, 107Ð134.
ANGUS, T. A.(1954). A bacterial toxin paralyzing silkworm larvae. Nature 173, 545Ð546.
ANGUS, T. A.(1968). Similarity of effect of valinomycin and Bacillus thuringiensis parasporal protein in
larvae of Bombyx mori. J. Invertebr. Pathol. 11, 145Ð146.
BERRIDGE, M. J. AND PATEL, N. G. (1968). Insect salivary glands: Stimulation of fluid secretion by 5-hydroxytryptamine and adenosine-39,59-monophosphate. Science 162, 462Ð463.
BERTRAM, G., SCHLEITHOFF, L., ZIMMERMANN, P. AND WESSING, A. (1991). Bafilomycin A1 is a potent
inhibitor of urine formation by Malpighian tubules of Drosophila hydei: is a vacuolar-type ATPase
involved in ion and fluid secretion? J. Insect Physiol. 37, 201Ð209.
CIOFFI, M.(1979). The morphology and fine structure of the larval midgut of a moth (Manduca sexta) in
relation to active ion transport. Tissue & Cell 11, 467Ð479.
CIOFFI, M. AND WOLFERSBERGER, M. G. (1983). Isolation of separate apical, lateral and basal plasma
membrane from cells of an insect epithelium. A procedure based on tissue organization and
ultrastructure. Tissue & Cell 15, 781Ð803.
DOW, J. A. T. (1984). Extremely high pH in biological systems: a model for carbonate transport. Am. J.
Physiol. 246, 633Ð635.
DOW, J. A. T.(1986). Insect midgut function. Adv. Insect Physiol. 19, 187Ð328.
Dow, J. A. T. AND O'DONNELL, M. J. (1990). Reversible alkalinization by Manducasexta midgut. J. exp.
Biol. 150, 247Ð256.
DOW, J. A. T., GUPTA, B. L., HALL, T. A. AND HARVEY, W. R.(1984). X-ray microanalysis of elements in
frozen-hydrated sections of an electrogenic K+ transport system: the posterior midgut of tobacco
hornworm (Manduca sexta) in vivo and in vitro. J. Membr. Biol. 77, 223Ð241.
DOW, J. A. T. AND HARVEY, W. R. (1988). Role of midgut electrogenic K+ pump potential difference in
regulating lumen K+ and pH in larval lepidoptera. J. exp. Biol. 140, 455Ð463.
GEISER, M., SCHWEITZER, S. AND GRIMM, C. (1986). The hypervariable region in the genes coding for
entomopathogenic crystal proteins of Bacillus thuringiensis: nucleotide sequence of the kurhd1 gene
of subsp. kurstaki HD1. Gene 48, 109Ð118.
GUPTA, B. L. AND BERRIDGE, M. J.(1966). A coat of repeating subunits on the cytoplasmic surface of the
plasma membrane in the rectal papillae of the blowfly, Calliphora erythrocephala (Meig.), studied in
situ by electron microscopy. J. CellBiol. 29, 376Ð382.
HARVEY, W. R. (1980). Water and ions in the gut. In Insect Biology in the Future 'VBW 80' (ed. M.
Locke and D. S. Smith), pp. 105Ð124. New York: Academic Press.
HARVEY, W. R. (1982). Membrane physiology of insects. In Membrane Physiology of Invertebrates
(ed. R. B. Podesta), pp. 495Ð566. New York: Marcel Dekker.
HARVEY, W. R.(1992). Physiology of V-ATPases. J. exp. Biol. 172, 1Ð17.
HARVEY, W. R., C IOFFI, M. AND WOLFERSBERGER, M. G. (1986). Transport physiology of lepidopteran
midgut in relation to the action of Bt delta-endotoxin. In Fundamental and Applied Aspects of
Invertebrate Pathology (ed. R. Samson, J. Vlak and D. Peters), pp. 11Ð14. Wangeningen: Foundation
IVth Int. Colloq. Invertebr. Pathol.
HARVEY, W. R. AND NEDERGAARD, S. (1964). Sodium independent active transport of potassium in the
isolated midgut of the cecropia silkworm. Proc. natn. Acad. Sci. U.S.A. 51, 757Ð765.
HARVEY, W. R. AND WOLFERSBERGER, M. G. (1979). Mechanism of inhibition of active potassium
transport in isolated midgut of Manduca sexta by Bacillus thuringiensis endotoxin. J. exp. Biol. 83,
293Ð304.
HARVEY, W. R. AND ZERAHN, K. (1971). Active transport of sodium by the isolated midgut of
Hyalophora cecropia. J. exp. Biol. 54, 269Ð274.
HARVEY, W. R. AND ZERAHN, K. (1972). Active transport of potassium and other alkali metals by the
isolated midgut of the silkworm. Current Topics Membr. Transport 3, 367Ð410.
HASKELL, J. A., HARVEY, W. R. AND CLARK, R. W. (1968). Active transport by the Cecropia midgut. V.
Loss of potassium transport during larvalÐpupal transformation. J. exp. Biol. 48, 25Ð37.
HILLE, B. (1992). Ionic Channels of Excitable Membranes, 2nd edn. Sunderland: Sinauer.
HOEFTE, H. AND WHITELEY, H. R. (1989). Insecticidal crystal proteins of Bacillus thuringiensis.
Microbiol. Rev. 53, 242Ð255.
HOFMANN, C., LUETHY, P., HUETTER, R. AND PLISKA, V. (1988). Binding of the delta endotoxin from
V-ATPases and insect control
Bacillus thuringiensis to brush border membrane vesicles of the cabbage butterfly (Pieris brassicae).
Eur. J. Biochem. 173, 85Ð91.
HUBER, H. E. AND LUETHY, P. (1981). Bacillus thuringiensis delta-endotoxin: composition and
activation. In Pathogenesis of Invertebrate Microbial Diseases (ed. E. W. Davidson), pp. 209Ð233.
Totowa: Allanheld.
ISHIWATA, S. (1901). On a kind of severe flacherie (sotto disease). Dainihon Sanshi Keiho 9, 1Ð5.
JAQUET, F., HUETTER, R. AND LUETHY, P. (1987). Specificity of Bacillus thuringiensis delta-endotoxin.
Appl. environ. Microbiol. 53, 500Ð504.
KAFATOS, F. C. (1968). The labial gland: A salt-secreting organ of saturniid moths. J. exp. Biol. 48,
435Ð453.
KEYNES, R. D. (1969). From frog skin to sheep rumen: A survey of transport of salts and water across
multicellular structures. Q. Rev. Biophys. 2, 177Ð281.
KLEIN, U. (1992). The insect V-ATPase, a plasma membrane proton pump energizing secondary active
transport: immunological evidence for the occurrence of a V-ATPase in insect ion-transporting
epithelia. J. exp. Biol. 172, 345Ð354.
KUEPPERS, J. AND THURM, U. (1979). Active transport by a sensory epithelium. I. Transepithelial short
circuit current, potential difference, and their dependence on metabolism. J. comp. Physiol. 134,
131Ð136.
LUETHY, P., CORDIER, J.-L. AND FISCHER, H.-M. (1982). Bacillus thuringiensis as a bacterial insecticide:
basic considerations and application. In Microbial and Viral Pesticides (ed. E. Kurstak), pp. 35Ð74.
New York: Marcel Dekker.
LUETHY, P. AND EBERSOLD, H. R. (1981). Bacillus thuringiensis delta-endotoxin: histopathology and
molecular mode of action. In Pathogenesis of Invertebrate Microbial Diseases (ed. E. W. Davidson),
pp. 235Ð268. Totowa: Allanheld.
LUETHY, P., JAQUET, F., HOFMANN, C., HUBER-LUKAC, M. AND WOLFERSBERGER, M. G. (1986).
Pathogenic actions of Bacillus thuringiensis toxin. Zentralbl. Bakt. Mikrobiol. Hyg. I. (Suppl.) 15,
161Ð166.
MANDEL, L. J., M OFFETT, D. F. AND JOBSIS, F. F. (1975). Redox state of respiratory chain enzymes and
potassium transport in silkworm midgut. Biochim. biophys. Acta 408, 123Ð134.
MANDEL, L. J., R IDDLE, T. G. AND STOREY, J. M. (1980). Role of ATP in respiratory control and active
transport in tobacco hornworm midgut. Am. J. Physiol. 238, C10ÐC14.
MOFFETT, D. F. AND KOCH, A. (1992). Driving forces and pathways for H+ and K+ transport in insect
midgut goblet cells. J. exp. Biol. 172, 403Ð415.
RAMSAY, J. A. (1953). Active transport of potassium by the Malpighian tubules of insects. J. exp. Biol.
30, 358Ð369.
SACCHI, V. F., PARENTI, P., HANOZET, G. M., GIORDANA, B., LUETHY, P. AND WOLFERSBERGER, M. G.
(1986). Bacillus thuringiensis toxin inhibits K-gradient-dependent amino acid transport across the
brush border membrane of Peirisbrassicae midgut cells. FEBS Lett. 204, 213Ð218.
SLATIN, S. L., ABRAMS, C. K. AND ENGLISH, L. (1990). Delta-endotoxins form cation-selective channels
in planar lipid bilayers. Biochem. biophys. Res. Commun. 169, 765Ð772.
THURM, U. AND KUEPPERS, J. (1980). Epithelial physiology of insect sensilla. In Insect Biology in the
Future'VBW 80' (ed. M. Locke and D. S. Smith), pp. 735Ð763. New York: Academic Press.
TURBECK, B. O., NEDERGAARD, S. AND KRUSE, H. (1968). An anion-stimulated adenosine triphosphatase
from the potassium-transporting midgut of the larva of Hyalophora cecropia. Biochim. biophys. Acta
163, 354Ð361.
VANRIE, J., JANSENS, S., HOEFTE, H., DEGHEELE, D. and VANMELLAERT, H. (1989). Specificity of
Bacillus thuringiensis delta-endotoxins: importance of specific receptors on the brush border
membranes of the midgut of target insects. Eur. J. Biochem. 186, 239Ð247.
VANRIE, J., JANSENS, S., HOEFTE, H., DEGHEELE, D. AND VANMELLAERT, H. (1990). Receptors on the
brush border membrane of the insect midgut as determinants of the specificity of Bacillus
thuringiensis delta-endotoxins. Appl. environ. Microbiol. 56, 1378Ð1385.
WIECZOREK, H. (1982). A biochemical approach to the electrogenic potassium pump in insect sensilla:
potassium sensitive ATPases in the labellum of the fly. J. comp.Physiol. A 148, 303Ð311.
WIECZOREK, H. (1992). The insect V-ATPase, a plasma membrane proton pump energizing secondary
active transport: molecular analysis of electrogenic potassium transport in the tobacco hornworm
midgut. J. exp. Biol. 172, 335Ð343.
386 M. G. WOLFERSBERGER
WIECZOREK, H., PUTZENLECHNER, M., ZEISKE, W. AND KLEIN, U. (1991). A vacuolar-type proton pump
energizes K+/H+ antiport in an animal plasma membrane. J. biol. Chem. 266, 15340Ð15347.
WIECZOREK, H., WOLFERSBERGER, M. G., CIOFFI, M. AND HARVEY, W. R. (1986). Cation-stimulated
ATPase activity in purified plasma membranes from tobacco hornworm midgut. Biochim. biophys.
Acta 857, 271Ð281.
WOLFERSBERGER, M. G. (1979). A potassium-modulated plasma membrane adenosine triphosphatase
from the midgut of Manduca sexta larvae. Fedn Proc. Fedn Am. Socs exp. Biol. 38, 242.
WOLFERSBERGER, M. G. (1990). The toxicity of two Bacillus thuringiensis delta-endotoxins to gypsy
moth larvae is inversely related to the affinity of binding sites on midgut brush border membranes for
the toxins. Experientia 46, 475Ð477.
WOLFERSBERGER, M. G., HARVEY, W. R. AND CIOFFI, M. (1982). Transepithelial potassium transport in
insect midgut by an electrogenic alkali metal ion pump. Current Topics Membr. Transport 16,
109Ð133.
WOLFERSBERGER, M. G., HOFMANN, C. AND LUETHY, P. (1986). Interaction of Bacillus thuringiensis
delta-endotoxin with membrane vesicles isolated from lepidopteran larval midgut. Zentralbl. Bakt.
Mikrobiol. Hyg. I. (Suppl.) 15, 237Ð238.
WOOD, J. L., FARRAND, P. S. AND HARVEY, W. R.(1969). Active transport of potassium by the Cecropia
midgut. VI. Microelectrode potential profile. J. exp.Biol. 50, 169Ð178.
ZEISKE, W. (1992). Insect ion homeostasis. J. exp. Biol. 172, 323Ð334.