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Figure 5


Fig. 5. Membrane potential (Vm) changes in acinar cells induced by electrical salivary duct nerve (SDN)-stimulation (A,C). Asterisks mark the timepoints of electrical stimulation (5 V, 0.2 ms, 5 Hz, 2 s trains). The black arrow in A indicates the hyperpolarization, the open arrow the depolarization induced by one train of electrical stimuli. The box in C indicates the response shown in A. (B) Dose-response relations determined from the changes in Vm induced by bath application of increasing dopamine (black line, means ± s.e.m., N=7) and serotonin (broken line, means ± s.e.m., N=7) concentrations. The mean change in Vm recorded from acinar cells upon electrical SDN-stimulation (13 mV; black line, N=21) is within the dynamic range of the dose-response relations for both neurotransmitters. (D) Bath application of GABA (5 µmol l–1) during SDN-stimulation leads to enhanced amplitudes of the electrical responses recorded from acinar cells. The response amplitudes recover after GABA washout. (E) Comparison of the amplitudes of changes in Vm induced by SDN-stimulation in the absence (control) and in the presence of GABA (N=21, means ± s.e.m.). The mean amplitude of at least two or more consecutive control stimulations was compared by a paired t-test to the mean amplitude of at least two or more stimulations during bath application of GABA. ***P<0.0001.





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