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Figure 4


Fig. 4. Changes in the membrane potential (Vm) recorded from acinar cells during bath application of GABA, dopamine and 5-HT. (A) Superfusion of isolated salivary glands with PS containing 1 mmol l–1 GABA does not affect the resting Vm of acinar cells. Control application of 100 nmol l–1 dopamine evokes multiphasic changes in the Vm of the acinar cell, showing that the isolated gland is functionally intact. (B,D) Co-application of GABA and either dopamine or serotonin (5-HT). 1 mmol l–1 GABA has no measurable effect on the amplitudes and kinetics of dopamine- or 5-HT-induced Vm changes in acinar cells. (C) Quantitative summary (means ± s.e.m.) of the experiments illustrated in B and D. Response amplitudes induced by co-application of dopamine or 5-HT and GABA, normalized to control amplitudes with 5-HT or dopamine, respectively, prior to co-application. The amplitude was taken as the range from the hyperpolarization peak to the depolarization peak. 1 mmol l–1 GABA did not significantly alter the dopamine-(N=5) and 5-HT-induced (N=6) changes in Vm. Duration of dopamine, 5-HT and GABA applications are indicated by bars.





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