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Figure 4


Fig. 4. Postnatal time-course of expression of MyHC isoforms (A) and the influence of individual MyHC isoforms on isometric stress (B–G). Sample MyHC gels of P1 and P28 muscle are shown next to the legend in A. The embryonic (EMB), neonatal (NEO), and IIX and IIB mature isoforms were all significantly correlated with contractile function (P<0.001 for each, R2EMB=0.48, R2NEO=0.72, R2IIX=0.46, R2IIB=0.62), although NEO was the strongest predictor as determined by stepwise multiple regression. Neither isoform I nor IIA was significantly correlated with contractile function (P>0.05 for each, R2I=0.09, R2IIA=0.01). *P<0.05 relative to the previous time-point.





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