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Figure 5


Fig. 5. Agonist pharmacology of inhibitory glutamate receptors in Helisoma buccal neurons. (A) ACPD, DCG-IV and quisqualate (Quis) reduced AP frequency in individual B5, B19 and B27 neurons, respectively. Membrane potential was measured with standard intracellular recording techniques. Drugs were applied during the times indicated by the horizontal lines. Arrowheads indicate 0 mV. (B) mGluR agonists Quis (10 µmol l–1) and ACPD (100 µmol l–1) significantly reduced mean (±s.e.m.) AP frequency of B5 neurons (*P<0.007, N=15 and 13, respectively). DHPG, DCG-IV and L-AP4 (all N=6) had no effect on firing rate. (C) Quis (10 µmol l–1) significantly reduced mean (±s.e.m.) AP frequency in B19 neurons (#P<0.0001, N=20). ACPD (N=14), DHPG (N=9), DCG-IV (N=8) and L-AP4 (N=7) had no effect on AP frequency. (D) Quis (10 µmol l–1) significantly reduced mean (±s.e.m.) AP frequency of B27 neurons (+P<0.05, N=9), whereas ACPD (N=4), DHPG (N=8), DCG-IV (N=8) and L-AP4 (N=7) had no effect.





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