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Fig. 3. Model comparisons of 1st-order (A) versus Michaelis-Menten (B)
reaction kinetics on time courses of central O2 concentrations
during step-change experiments (i.e. external concentration changed from 280
to 0 nmol cm–3 and then vice versa). Under
first-order reaction kinetics, larger
gives
larger initial drawdown (see Fig.
2), and the step-down and step-up-traces are always symmetrical.
Analogously, under Michaelis–Menten kinetics, larger Vmax
gives greater initial drawdown. However, here the step-down and step-up-traces
are asymmetrical, with the asymmetry exaggerated by larger initial
drawdown.