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Fig. 7. Time course of activation of the swelling-induced membrane current. (A)
Dependence of the swelling-activated membrane current on
Em at different times after reducing the extracellular
osmolality (–40 mmol l–1 NaCl). Retzius neurons were
clamped from a holding potential of –50 mV to –100, –80,
–60 or –40 mV for 1 s with an interstimulus interval of 2 s (see
Fig. 6A). This protocol was
applied in SLS as well as 50, 100... 300 s after changing the extracellular
osmolality to obtain the presented I–V relationships.
Data are means ± s.d. of N=5 experiments. (B) Time course of
the activation and deactivation of the swelling-induced membrane current, as
derived from the data shown in A, as well as from current recordings after
return to SLS. Activation and deactivation of the swelling-induced current
occurred with a similar time course to the changes in cell volume (compare
Fig. 2C,
Fig. 5A,
Fig. 10A,B).
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