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Figure 3


Fig. 3. Effect of reducing the extracellular NaCl concentration on Em, Rin and the generation of action potentials. (A) Continuous recording showing the effect of reducing the extracellular NaCl concentration by 40 mmol l–1 for 5 min. Upward deflections are spontaneous action potentials, downward deflections were caused by the injection of negative current (–5 nA, duration 1 s, pulse interval 10 s). (B) Segment of the trace in A on an expanded time scale, shortly before and after the reduction of the extracellular NaCl concentration, as indicated. Action potentials truncated due to high gain. Note the partial recovery of the current-induced hyperpolarization (`depolarizing sag', arrow), which is due to the activation of hyperpolarization-activated (Ih) channels. (C) Rin calculated from the current-induced hyperpolarization shown in B.





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