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Figure 4


Fig. 4. Circularized RGD-peptides modulate activation of endoneurial phagocytes in vitro. (A) Percentage of endoneurial phagocytes showing a spreading response after culturing in the presence of fibronectin-coated microspheres in ABS only, and in the presence of ABS + 10 nmol l–1 cGRGDSPA, ABS + 1 µmol l–1 cGRGDSPA or ABS + 100 µmol l–1 cGRGDSPA. (B) Percentage of spreading endoneurial phagocytes that engulfed fibronectin-coated microspheres when cultured in ABS only, and in the presence of ABS + 10 nmol l–1 cGRGDSPA, ABS + 1 µmol l–1 cGRGDSPA or ABS + 100 µmol l–1 cGRGDSPA. Treatment with cGRGDSPA had a significant concentration-dependent biphasic effect on both the percentage of spreading cells and the percentage of phagocytic active cells. (C) Distribution of the number of engulfed fibronectin-coated microspheres by spreading cells is shifted to the right, i.e. more microspheres are engulfed, when the cells were cultured in ABS only compared with the cells cultured in the presence of 1 µmol l–1 cGRGDSPA.





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