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Fig. 1. Amino acid alignment for insulin-like growth factor binding proteins
(IGFBP) 1–6. Conserved cysteine residues are indicated by a bold
asterisk above the alignment. The CWCV and GCGCCXXC, RGD and heparin binding
motifs are highlighted in bold text. The predicted nuclear localisation signal
for IGFBP-5.1 is underlined. The asterisks below the alignment indicate
completely conserved residues; :, indicates highly conserved
residues;., indicates less conserved residues.