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Fig. 4. Work and ATP utilization vary with respect to the phase of Ca2+
activation (
Ca). Data points (connected with a line) represent
average values (mean ± s.d.) from 245 individual work loops at a duty
cycle (
Ca) of 0.5. The
Ca values producing
maxima and minima varied for work (A) and ATP (B), therefore yielding a unique
Ca that maximized efficiency (ratio of work to ATP; C). Strain
amplitude
was 0.05 (left) and 0.025 (right), and primarily affected
work magnitude. Note the difference in ordinate scales between the left and
right panels in A and C when
=0.05 versus 0.025. Mechanical
parameters for the filaments and cross-bridges are listed in
Fig. 2.