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Figure 6


Fig. 6. Proposed model of the two different pathways for sulfide oxidation in the mitochondria of Arenicola marina. A membrane-bound sulfide:quinone oxidoreductase (SQR) oxidizes sulfide (H2S) to persulfides (R-SSH; R=cysteine residue of the SQR) and transfers the electrons to the ubiquinone pool (Theissen and Martin, 2008). In the presence of GSH and ascorbate, representing reducing cellular conditions, a pathway of sulfide detoxification is activated (A). Electrons are transferred to oxygen via an alternative oxidase (AOX) without proton translocation. The energy-conserving sulfide oxidation pathway can be activated by dehydroascorbate (DHA) in vitro (B). Electrons are channelled to oxygen through the classical respiratory chain complexes III and IV, which transport protons across the membrane, thus allowing ATP production by complex V (ATP synthase). Inhibitors used in this study are specified above their target enzymes.





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