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Figure 4


Fig. 4. Calcium uptake and release by isolated mitochondria. Extra-mitochondrial free calcium concentration was measured with the calcium probe fluo-5N. (A) Energized mitochondria from A. franciscana lowered the concentration of exogenously added Ca2+ at all concentrations investigated compared with controls (no mitochondria present). Calcium-induced calcium release was not observed, consistent with the lack of MPTP opening. (B) Rat liver mitochondria reduced the free Ca2+ concentration only in the case where no exogenous Ca2+ was added. Upon addition of 0.1 mmol l–1 Ca2+, release of calcium was observed, indicating MPTP opening. For further explanation, refer to text. Each bar represents the mean ± s.d. of N=3 experiments. *Significantly different from control (P<0.05) (modified from Menze et al., 2005b).





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