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Figure 4


Fig. 4. GABA (10 nmol l–1–10 mmol l–1) modulation of 3[H]-TBOB (t-butylbicycloorthobenzoate) binding in the CIC of young and aged F344 rats. The dose–response curve is shifted to the left. These data have functional implications since the aged GABAA receptor must be more sensitive to GABA than the young GABAA receptor for the channel to be open allowing TBOB to bind to the picrotoxin binding site. (Modified from Milbrandt et al., 1996.)





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