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Fig. 3. Vestibular ganglion somata produce either transient or sustained firing patterns in response to small depolarizing currents. (A,B) Voltage responses of two isolated somata to steps of +50 pA, recorded in whole-cell current clamp. Small depolarizing currents (4–200 pA) evoke single spikes (transient responses) in some neurons (A) and multiple spikes (sustained responses) in others (B). Somata dissociated from the mouse vestibular ganglion were recorded in the first postnatal week with a standard high-K⁺ pipette solution and a bath of L-15 medium. Similar results have been obtained with perforated patch recordings and from rat vestibular ganglion somata (J.X., R.K. and R.A.E., unpublished observations). Arrows point to AHPs after the first spike and the offset of the step; AHPs have longer repolarizing phases in the neuron with the sustained response (B). (C,D) Whole-cell current responses to voltage steps, recorded in voltage clamp from the same neurons as in A,B. Depolarizing steps (bottom panel) evoked large brief Na⁺ currents followed by large steady outward K⁺ currents. The sustained neuron (D) had prominent A and h currents, but it is not established that these differences influence the spike pattern.

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