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Fig. 4. Hypothesized models for the organization of the covalently bound
sphingolipids in the SC in house sparrows from mesic and desert environments.
(A) Water shell model. The hexose group of cerebrosides would sequester water
molecules. Desert sparrows, with more cerebrosides, could hold a higher amount
of water, therefore reducing rates of CWL. (B) Hexose link model. Hexose
molecules from cerebrosides would establish molecular interactions with the
sphingosine heads of the ceramides that form the outer layer of the
intercellular lamellae. In both models, covalently bound ceramides connect
adjacent corneocytes.
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