spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 5


Fig. 5. Reduced levels of Mlp84B result in a slower heart beat due to prolongation of the diastolic interval. (A) Heart period is significantly longer in 1 week old mlp84B–/– flies compared with age-matched wild-type (wt) controls. Reintroduction of a mlp84B transgene in the mlp84B–/– background results in partial rescue. (B) Heart-specific mlp84B knockdown prolongs the heart period in 5 week old flies compared with age-matched wild-type or UAS-mlp84B-RNAi outcrossed to wild-type flies. No significant increase in heart period was observed in 1 week old mlp84B RNAi-expressing flies. (C,D) Diastolic interval is significantly longer in 1 week old mlp84B–/– and 5 week old mlp84B RNAi-expressing flies compared with corresponding controls (as in A and B). mlp84B–/– rescue flies show intermediate diastolic interval duration (C). No significant prolongation of the diastolic interval was detected in mlp84B RNAi-expressing flies at 1 week of age (not shown). See supplementary material Fig. S1 for increases in standard deviations of the heart period and diastolic interval of 1 week old mlp84B–/– flies and 5 week old mlp84B RNAi-expressing flies.





Right arrow Return to article