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Figure 1


Fig. 1. Developmental cardiac expression and localization of Mlp84B. (A) Alignment of the first LIM domain glycine-rich region from human CRP1, 2 and 3 (CRP3=MLP) and Drosophila Mlp84B and Mlp60A. The first residue highlighted is a mutation associated with human dilated cardiomyopathy (see Knöll et al., 2003), while the other three highlighted residues are associated with cardiac hypertrophy (see Geier et al., 2003). (B) Stage 17 embryo stained with Mlp84B antiserum. The heart tube is delineated by arrows. (C) Image montage of a heart tube dissected from a mlp84B::GFP 3rd instar larva. Expression can be seen in sarcomeres as well as in cell nuclei. (D) Posterior part of a wild-type 3rd instar larva heart (segment A6) stained with Mlp84B antiserum. (E–G) Detail of the cardiac myofibrils in the larval heart showing co-localization of {alpha}-actinin and Mlp84B. All scale bars are 50 µm.





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