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Fig. 3. Genetic hubs and genetic disease in humans. Genetic hubs are genes that
when inactivated can enhance the phenotypic consequence of mutations in many
different genes. Often hub genes can enhance the consequences of mutations in
genes acting in diverse functionally unrelated pathways. Examples include a
set of chromatin-modifying genes in C. elegans (the genes mys-1,
trr-1, dpy-22, hmg-1.2, din-1, and egl-27)
(Lehner et al., 2006b), the
Prefoldin complex in S. cerevisiae
(Tong et al., 2004), and the
gene hsp90 in yeast (Zhao et al.,
2005), flies (Rutherford and
Lindquist, 1998) and plants
(Queitsch et al., 2002). Here
the red node represents a hub gene, and the remaining nodes are coloured
according to their function. Protein–protein interactions are shown as
solid lines and genetic interactions as broken lines.
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