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Fig. 2. Within- and between-pathway models for genetic interactions. Synthetic
lethal interactions (broken lines) can occur both between two components of a
single biochemical pathway (A), or between components of two parallel pathways
that can functionally compensate for each other (B). Kelley and Ideker found
that the combination of within- and between-pathway models could explain about
40% of synthetic lethal or sick interactions in yeast, with between-pathway
models predominating. Examples of within-pathway interactions include
interactions among components of the spliceosome, and interactions among
components of the casein kinase 2 complex. Between-pathway interactions
include extensive interactions between components of the Dynactin complex and
components of the Prefoldin complex
(Kelley and Ideker, 2005). For
interactions between partial loss-of-function mutations, however,
within-pathway models may predominate. Genes/proteins are shown as nodes,
protein interactions as solid edges, and genetic interactions as broken
edges.
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