spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. Synthetic genetic interactions. A synthetic lethal interaction between two genes is defined when the survival of the combined mutation is less than the product of the survival of the two single mutations. In yeast, genetic interactions are defined by combining mutant strains using systematic mating protocols (A), and synthetic lethal or sick phenotypes are defined where a double mutant strain displays a phenotype that is not seen with either single mutant strain. In C. elegans, genetic interations are defined by combining genetic mutations with RNAi to target a second gene (B), or by using combinatorial RNAi to target two genes simultaneously (C) (Tischler et al., 2006). Synthetic aggravating phenotypes can be similarly defined for other phenotypes such as sterility or growth (Lehner et al., 2006b), and many more possible combinations of aggravating or alleviating interactions are also possible (Drees et al., 2005).





Right arrow Return to article