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Figure 1


Fig. 1. Dopamine (DA)-induced changes in pHi in duct cells of isolated salivary glands as measured with BCECF (A,B) and a double-barrelled pH-sensitive microelectrode (C). (A) Treatments with 1 µmol l–1 and 100 nmol l–1 DA induce a reversible intracellular acidification, N=5. (B) Dose–response relationship of the DA-induced intracellular acidification. Experiments were performed as in A and responses were normalised to the pHi drop induced by a first 1 µmol l–1 DA control stimulus (=100%). Values are means ± s.e.m. from 4–7 experiments for each concentration. A non-linear regression according to the Hill equation was fitted through the data points. (C) Effect of DA on pHi (solid line) and basolateral membrane potential (PDb, broken line). This recording, with a double-barrelled pH-sensitive microelectrode, is representative of five independent experiments.





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