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Figure 1


Fig. 1. Cell death after polyethylene glycol (PEG) application to acrolein-treated PC12 cells. (A–C) Control PC12 cells are shown developing on the culture substrate. Notice that these cells were well attached and some have extended processes giving them a stellate appearance. (A') The same culture as in A, 4 h after a `sham treatment' – the introduction of PBS into the culture medium. Notice that all cells in this field of view are healthy, developing and all together similar to the culture 4 h previously. (B') The same culture as in B, 4 h after the introduction of 100 µmol l–1 acrolein. Note the significant loss of cells with cell debris littering the substrate. (C') The same culture as in C, showing significant cell death as a result of acrolein treatment, in spite of the addition of 10 mmol l–1 PEG to the culture medium within 15 min after acrolein.





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