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Fig. 4. Production of Ins(1,4,5)P₃ by MHC class I peptides. MHC class I peptides have the ability to stimulate the production of Ins(1,4,5)P₃ in vomeronasal organ (VNO) microvillar preparations from female C57BL/6 mice. Reactions were performed without stimulus (PBS only), with whole urine, or active and inactive forms of the H-2^b and H-2^d haplotype peptides. Synthetic BALB/c peptide (H-2^d) stimulates the production of Ins(1,4,5)P₃ in the VNO (*P<0.05). The synthetic C57 peptide (H-2^b) does not significantly increase Ins(1,4,5)P₃ production, and the alternative forms of both peptides result in Ins(1,4,5)P₃ levels approximately equal to basal levels, indicating their inability to stimulate Ins(1,4,5)P₃ production in the VNO. Values are means ± s.e.m. of at least five independent experiments, each consisting of duplicate measurements.

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