|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 4. Immediate cooling after the one-trial conditioning procedure blocks
long-term memory (LTM) formation. (A) Snails (N=60) were subjected to
the one-trial conditioning procedure and were then immediately (within 30 s)
cooled to 4°C for 30 min. After cooling, snails were kept at room
temperature and tested 1 h (N=30) and 24 h (N=30) later.
There were no significant differences in the response to the conditioned
stimulus (CS) following conditioning and the immediate cold block (one-way
ANOVA). (B) Feeding response to the CS following the one-trial conditioning
procedure after delayed cooling. Snails were cooled as in A except that the
cooling was delayed until after the 10-min memory test. That is, rather than
immediate cooling, cooling was delayed for 11 min. In this experiment we
classified 20 snails as good performers (filled squares) and 10 (open squares)
as poor performers. The bar below the graph indicates the cooling period. The
x axis has a logarithmic scale. The differences between the feeding
response of the good performers and that of the poor performers were observed
for at least 24 h (*P<0.01, Student's t-test). All values
are means ± s.e.m. These data show that the necessary new protein
synthesis required for LTM is initiated within 10 min of conditioning.
|
