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Figure 2


Fig. 2. Aligned sequences of transmembrane domains of serotonin receptors of five species. All transmembrane domains showed high homology, but the number of domains were different. Shaded boxes show location of transmembrane domains, based on SOSUI analysis. The transmembrane domains are numbered from the N terminus. Although serotonin receptor 5HT-1A of S. purpuratus lacked the 6th and 7th transmembrane domains (SOSUI analysis), two additional C-terminal transmembrane domains at equivalent regions to the other serotonin receptors were predicted both by SOSUI analysis using the C-terminal region alone (open rectangles) and TMpred (underlined), respectively. First domain of Scallop was at the N-terminal end from Met1 to Asp23, thus was not shown in this figure. 5Hthpr, H. pulcherrimus; Scallop, 5HT receptor of Mizuhopecten yessoensis; Aplysia, 5HT receptor of Aplysia californica; Fugu, 5HT receptor of Takifugu rubripes; S.p., S. purpuratus 5HT-1A.





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