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Figure 2


Fig. 2. (A) 3-D structure model of Drosophila melanogaster MHC head region (i.e. incomplete MHC), showing theoretical calpain digestion sites (marked as red and blue spheres). Regions that would be excluded from Spot 6 due to digestion by calpain are shown in grey. (B) Protein sequence alignment for three insect species of MHC head region in which theoretical calpain digestion sites are located. One such site (Lys560–Ser561) is present for the mosquito Anopheles gambiae (A. gam), while both sites are present for the fruitfly Drosophila melanogaster (D. mel) and honey bee Apis mellifera (Ap. mel; Lys561–Ser562 and Lys613–Ser614, respectively).





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