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Fig. 9. A model of paracrine and autocrine EDN1 signaling in the fish gill. The
diagram shows a lamellar cross-section (see Figs
5,
6,
7) with pillar cells (PCs) in
gray, pavement cells (PVCs) and a lamellar arteriole (LA) adjacent to the
interlamellar region of the gill containing mitochondrion rich-cells (MRCs), a
neuroendocrine cell (NEC), and the gill vasculature. Cyclo-oxygenase-2 (COX-2)
and neuronal nitric oxide were previously immunolocalized in the killifish
gill (Choe et al., 2006;
Hyndman et al., 2006). NKA and
the cystic fibrosis transmembrane conductance regulator (CFTR) are used as
markers for the MRC (Katoh et al.,
2001). See text for details.
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