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Fig. 1. Maximum likelihood analyses of the vertebrate preproendothelin amino acid
sequences. Following the WAG model of amino acid substitutions
(Whelan and Goldman, 2001) and
a gamma=1.023, there are three distinct groups of preproendothelins,
preproendothelin-1 (abbreviated as only EDN1 to save space),
preproendothelin-2 (EDN2) and preproendothelin-3 (EDN3). Numbers at nodes
represent the percent bootstrap (BS=500 replications). GenBank accession or
Ensembl numbers: Chicken EDN1, XP_418943; chicken EDN2, XP_417707; chicken
EDN3, XP_001231488; frog EDN1, AAS13535.1; frog EDN3, AAS13536.1; human EDN1,
NP_001946; human EDN2, NP_001947; human EDN3, NP_000105; killifish EDN1A,
EU009474; killifish EDN1B, EU009475; medaka EDN1, ENSORLP00000011633; medaka
EDN2, ENSORLP00000010557; medaka EDN3, ENSORLP00000011814; mouse EDN1,
NP_034234; mouse EDN2, P22389; mouse EDN3, NP_031929; rat EDN1, NP_036680; rat
EDN2, NP_036681; rat EDN3, NP_001071118; salmon EDN1, BAF30875.1;
Takifugu EDN2, NEWSINFRUP00000182956; Takifugu EDN3,
NEWSINFRUP00000181774; Tetraodon EDN3, GSTENT00028275001;
Tetraodon EDN2, GSTENT00026224001; Zebrafish EDN1, NP_571594;
Zebrafish EDN2, NP_001038650. Scale bar represents the number of replacements
per site.
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