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Fig. 2. Uncaging of GTP-
-S increases the relative K+ conductance
of the membrane. (A) Effects of Leydig neuron stimulation (LS) before and
after a UV pulse (UV) to uncage GTP--S on the membrane potential. After
the membrane hyperpolarization following uncaging of GTP--S, LS had no
additional effect on the membrane potential, while raising the extracellular
K+ concentration from 4 to 10 mmol l–1 evoked a
large depolarization. The inset shows the effect of LS and UV pulses on a
non-injected cell. (B) Effects of 3 µmol l–1 myomodulin
(MMHir) and 10 mmol l–1 K+ before and
after a UV pulse uncaging GTP--S on the membrane potential. (C–E)
The membrane depolarization induced by 10 mmol l–1
K+ is larger (C,D), and faster rising (C,E), after uncaging of
GTP--S, indicating an increased relative K+ conductance.
*P<0.05. N represents the number of
experiments.
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