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Figure 1


Fig. 1. Changes in membrane potential (Em) and membrane resistance following uncaging of GTP-{gamma}-S. (A) Membrane potential recording of a giant glial cell injected with caged GTP-{gamma}-S, following moderate UV pulses (UV), the first of which hyperpolarized the cell membrane. (B) Changes in membrane potential following UV pulses; after a first (filled circles) and a second (open circles) UV pulse onto GTP-{gamma}-S-injected cells and after UV pulses of non-injected cells (open triangles). (C) Membrane input resistance (Rinput) measured by injection of square constant current pulses (upper trace), leading to brief deflection of the membrane potential (lower trace) before and after uncaging of GTP-{gamma}-S by a UV pulse. The inset shows superimposed potential traces at enhanced time scale before and after the UV pulse (indicated by shaded areas), showing a loss of input resistance after uncaging of GTP-{gamma}-S (D). (E,F) UV pulses onto non-injected cells had no effect on membrane potential or membrane resistance. **P<0.01.





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