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Figure 5


Fig. 5. Neighbor-joining guide phylogeny tree showing the relationship between 17 deduced Lospin polypeptides and 15 serpin sequences of other ticks. Deduced Lospin amino acid sequences were aligned with R. appendiculatus (Ras-1–4), H. longicornis (Hl) serpin, I. ricinus (Ir) serpin 1, 2, 4 and Iris=immunosuppressive Ixodes serpin, I. scapularis (Is) serpin and B. microplus (Bm) serpin 1–6. Note that, except for Bmserpin-5, which is annotated in GenBank, the other Bmserpins were obtained as ESTs from the TIGR database and translated in this study. Branch labels GA–GE, represent major groups of serpin sequences branching off from the outlier, the serpin superfamily archetype, {alpha}1-antitrypsin. *Accession numbers for Lospin sequences provided in the Results.





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