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Fig. 2. (A) Predicted Lospin reactive center loops (RCL). Lospin RCLs were
determined based on the eight-residue pattern (B) that characterizes
inhibitory serpins (Hopkins et al.,
1993). The residues in the RCL are numbered according to the
standard nomenclature (Schechter and
Berger, 1967), where residues on the amino-terminal side of the
scissile (p1–p1') are not primed and those on the carboxy-terminal
side are primed. Assuming that there are 17 residues between the base of RCL
hinge and the scissile bond (Hopkins et
al., 1993), bold-faced residues are predicted p1 residues with the
broken arrow indicating the position of the scissile bond.
L1–L17=Lospins 1–17.