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Fig. 1. Conservation of core serpin superfamily residues
(Irving et al., 2000) in
deduced Lospin proteins. The serpin superfamily archetype,
1-antitrypsin (
1-ATT, accession no.
AAB59495) was aligned with deduced Lospin (L) proteins using Vector NTI
(Invitrogen) and conserved residues were manually aligned.
L1–L17=Lospins 1–17. The minus sign (–) denotes conservation
of the specific amino acid residues. Replaced residues are indicated.
Numbering is based on
1-ATT. E%C denotes the expected %
conservation at that position (Irving et
al., 2000).