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Figure 2


Fig. 2. (A,B) The effects of the selective {alpha}1-adrenoceptor antagonist prazosine (Pr; 0.5 µmol l–1) and the selective {alpha}2-adrenoceptor antagonist RX821002 (RX; 25 µmol l–1) on the fictive lung ventilation frequency response to hypoxia measured in (A) the pre-metamorphic (control, N=7; Pr, N=5; RX, N=10) and (B) adult groups (control, N=7; Pr, N=6; RX, N=6). Note that in these figures, the control data (grey symbols; broken line) was transposed from Fig. 1 to facilitate comparisons. Trigeminal neurograms ({int}V, trigeminal nerve) showing changes in respiratory-related motor output under baseline and hypoxic conditions in the presence of the antagonists prazosine or RX 821002 in both stage groups are shown on the right. Values are means ± s.e.m. *Value statistically different from baseline at P<0.05.





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