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Figure 6


Fig. 6. Effects of pH changes on time course and amplitude of ICl,H. (A) A change from pH 7.2 to 8.4 leads to a faster time course of the hyperpolarisation-induced Cl– current. The amplitude, obtained by extrapolating the current until it reached steady state, was somewhat reduced. Voltage jump was as shown in B. (B) At pH 6.0 the amplitude became greatly reduced. The time course of the current appears to be slowed, yet in fact it remained unaffected, as found on fitting double exponentials to the current traces. Both pH effects were rapid; they were recorded {approx}1 min after changing the bath solution. The recordings labelled `wash' were made 3 to 5 min after changing back to pH 7.2. For a more detailed analysis of these effects see Table 1.





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