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Figure 5


Fig. 5. Steady-state activation of the chloride-conductance, GCl,H. (A) Mean GV relationship at two different internal Cl concentrations. Paired measurements of currents and of ECl were performed in six fibres after moderate and strong Cl loading of the fibre (the respective recordings were performed 1 and 5 min after impalement; for details of the approach and for the voltage-clamp protocols employed, cf. Materials and methods). Currents were converted to conductance, G. The conductance is greatly enhanced at raised [Cl]i. This effect is largely because of the increase in maximal conductance. (B) Normalised GV relationships for the data shown in A. The rise in [Cl]i led to some positive shift of the curve on the voltage axis. Curves in A and B are Boltzmann-fits. For further analysis, cf. Table 2. Error bars indicate s.e.m.





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