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Figure 4


Fig. 4. Changes in respiratory motor output during microinjection in the medullary Raphé. (A,B) Trigeminal neurograms showing the effects of glutamate microinjections in the medullary Raphé on fictive breathing (A) in the presence of artificial cerebrospinal fluid (aCSF) only and (B) in the presence of the selective 5-HT3 receptor antagonist tropisetron. (C,D) Control experiments consisted of measuring changes in trigeminal activity following (C) glutamate microinjection (1 nl, 0.5 mol l–1) 350 µm lateral to the medullary Raphé or (D) aCSF injection into the medullary Raphé. This figure also shows various types of burst activity observed following glutamate microinjection. Note that only bursts with a duration and amplitude similar to those observed prior to injections were counted as respiratory related (black bars). Bursts of a seizure-like activity or that were too long were not counted (grey bars).





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