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Fig. 10. p44ERK is regulated at the level of MEK during chemical anoxia/recovery
(A/R). Phosphorylation of MEK1 during A/R was analysed by western blotting
(top) and phospho-specific bands were quantified (bottom). (A) Anoxia inhibits
MEK in RTHD fibroblasts (N=4, *P<0.05). (B) Pre-treatment
with 10 µmol l–1 SB203580 for 1 h prevented inhibition of
MEK during anoxia (N=3, *P<0.05). (C) Pre-treatment with
100 nmol l–1 calyculin A (Cal. A) for 2 min blocked
reactivation of MEK during recovery (N=4, *P<0.05).
